The gooey cheese, crispy bread, and buttery goodness — how can someone resist a grilled cheese sandwich? There’s something so comforting about biting into the warm toast and cheese, which makes you give in to its flavors. 

If you’re wondering where to find the best-grilled cheese sandwiches in North Central Florida, your research ends here. We have the top-rated restaurants in the area rounded up just for you. Dive in!

Related Read: Top Restaurants Serving the Best Mozzarella Sticks in Gainesville

The Fat Tuscan Cafe
725 NE 1st St, Gainesville FL, 32601
Set in a 100-year-old fully restored historic building, this beautiful cafe is known for its classic grilled cheese sandwich with a twist. It is a stack of thick-sliced bread and three types of cheese. The winner is a dollop of pesto that adds a nutty and garlicky flavor to the sandwich.
Emiliano's Cafe
5.0  5 Rating (1)
7 SE 1st Ave, Gainesville FL, 32601
This cozy spot is famous for its traditional Spanish, Caribbean, and Latin American dishes. But its grilled cheese sandwich made with aged cheddar and gouda cheeses on whole-grain bread is equally delicious. Order their homemade tomato soup on the side — it’s flavorful and enhances taste by a good measure.
5 SE 2nd Ave, Gainesville FL, 32601
Nearly one decade and thousands of pizzas later, Big Lou is still a local favorite. While its pizza gets a lot of love, it’s not any different for its grilled cheese sandwich. Made with American cheese on white bread, it is the perfect comfort food.
Restaurant $$
1511 NW 2nd St, Gainesville FL, 32601
This charming café in Gainesville's historic district is a hidden gem for grilled cheese lovers. Served with a twist, the sandwich features cheddar and Swiss cheeses on hearty wheat bread. The unique bit is the side of sweet tomato jam for dipping. While it sounds weird, it’s a delicious combination!
Satchel's Pizza
1800 NE 23rd Ave, Gainesville FL, 32609
As the name suggests, Satchel’s Pizza is known for its delicious pizzas. But it also offers a tasty grilled cheese sandwich featuring cheddar and mozzarella cheeses on sourdough bread. The highlight is its side of marinara sauce for dipping. It’s a must-visit spot!